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Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists.
Takai, Kentaro; Inoue, Yasunao; Konishi, Yasuko; Suwa, Atsushi; Uruno, Yoshiharu; Matsuda, Harumi; Nakako, Tomokazu; Sakai, Mutsuko; Nishikawa, Hiroyuki; Hashimoto, Gakuji; Enomoto, Takeshi; Kitamura, Atsushi; Uematsu, Yasuaki; Kiyoshi, Akihiko; Sumiyoshi, Takaaki.
Afiliação
  • Takai K; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 3-1-98, Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan.
  • Inoue Y; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 33-94, Enoki-cho, Suita, Osaka 564-0053, Japan.
  • Konishi Y; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 3-1-98, Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan.
  • Suwa A; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 3-1-98, Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan.
  • Uruno Y; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 3-1-98, Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan.
  • Matsuda H; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 33-94, Enoki-cho, Suita, Osaka 564-0053, Japan.
  • Nakako T; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 33-94, Enoki-cho, Suita, Osaka 564-0053, Japan.
  • Sakai M; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 3-1-98, Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan.
  • Nishikawa H; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 33-94, Enoki-cho, Suita, Osaka 564-0053, Japan.
  • Hashimoto G; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 33-94, Enoki-cho, Suita, Osaka 564-0053, Japan.
  • Enomoto T; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 33-94, Enoki-cho, Suita, Osaka 564-0053, Japan.
  • Kitamura A; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 33-94, Enoki-cho, Suita, Osaka 564-0053, Japan.
  • Uematsu Y; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 3-1-98, Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan.
  • Kiyoshi A; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 33-94, Enoki-cho, Suita, Osaka 564-0053, Japan.
  • Sumiyoshi T; Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd, 3-1-98, Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan. Electronic address: t-sumiyo@kansai-u.ac.jp.
Bioorg Med Chem Lett ; 24(14): 3189-93, 2014 Jul 15.
Article em En | MEDLINE | ID: mdl-24856064
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Receptor Muscarínico M1 / Receptor Muscarínico M4 / Descoberta de Drogas / Indóis Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Receptor Muscarínico M1 / Receptor Muscarínico M4 / Descoberta de Drogas / Indóis Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article