Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls.
Cytotherapy
; 16(7): 1024-30, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24856897
ABSTRACT
BACKGROUND AIMS:
Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS).METHODS:
We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls.RESULTS:
Except for an increase in the number of C-C chemokine receptor 7-expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells.CONCLUSIONS:
Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Ativação Linfocitária
/
Receptores CCR7
/
Imunoterapia
/
Esclerose Múltipla
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article