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Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Wen, Wanqing; Zheng, Wei; Okada, Yukinori; Takeuchi, Fumihiko; Tabara, Yasuharu; Hwang, Joo-Yeon; Dorajoo, Rajkumar; Li, Huaixing; Tsai, Fuu-Jen; Yang, Xiaobo; He, Jiang; Wu, Ying; He, Meian; Zhang, Yi; Liang, Jun; Guo, Xiuqing; Sheu, Wayne Huey-Herng; Delahanty, Ryan; Guo, Xingyi; Kubo, Michiaki; Yamamoto, Ken; Ohkubo, Takayoshi; Go, Min Jin; Liu, Jian Jun; Gan, Wei; Chen, Ching-Chu; Gao, Yong; Li, Shengxu; Lee, Nanette R; Wu, Chen; Zhou, Xueya; Song, Huaidong; Yao, Jie; Lee, I-Te; Long, Jirong; Tsunoda, Tatsuhiko; Akiyama, Koichi; Takashima, Naoyuki; Cho, Yoon Shin; Ong, Rick Th; Lu, Ling; Chen, Chien-Hsiun; Tan, Aihua; Rice, Treva K; Adair, Linda S; Gui, Lixuan; Allison, Matthew; Lee, Wen-Jane; Cai, Qiuyin; Isomura, Minoru.
Afiliação
  • Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
  • Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
  • Okada Y; Laboratory for Statistical Analysis, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Hwang JY; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
  • Li H; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
  • Tsai FJ; School of Chinese Medicine, Department of Medical Genetics, Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
  • Yang X; Department of Occupational Health and Environmental Health, School of Public Health, Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
  • He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
  • He M; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Zhang Y; State Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Hypertension, Shanghai, China.
  • Liang J; Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu 221009, China.
  • Guo X; Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
  • Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, National Defense Medical Center, College of Medicine, Taipei, Taiwan, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Delahanty R; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
  • Guo X; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
  • Kubo M; Laboratory for Genotyping Development.
  • Yamamoto K; Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
  • Ohkubo T; Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan, Department of Health Science, Shiga University of Medical Science, Otsu, Japan.
  • Go MJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Liu JJ; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
  • Gan W; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
  • Chen CC; School of Chinese Medicine, Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan.
  • Gao Y; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China, College of General Practice, Guangxi Medical University, Nanning, Guangxi, China.
  • Li S; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • Lee NR; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu, Philippines.
  • Wu C; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Zhou X; Bioinformatics Division, Tsinghua National Laboratory of Information Science and Technology, Beijing, China.
  • Song H; State Key Laboratory of Medical Genomics, Ruijin Hospital, Molecular Medical Center, Shanghai Institute of Endocrinology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Yao J; Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Populations Sciences, Torrance, CA, USA.
  • Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Medicine, Chung-Shan Medical University, Taichung, Taiwan.
  • Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
  • Tsunoda T; Laboratory for Medical Science Mathematics.
  • Akiyama K; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Takashima N; Department of Health Science, Shiga University of Medical Science, Otsu, Japan.
  • Cho YS; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea, Department of Biomedical Science, Hallym University, Gangwon-do, Republic of Korea.
  • Ong RT; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, NUS Graduate School for Integrative Science and Engineering, Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore.
  • Lu L; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
  • Chen CH; School of Chinese Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Tan A; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
  • Rice TK; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
  • Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
  • Gui L; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Allison M; Department of Family and Preventive Medicine.
  • Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Department of Social Work, Tunghai University, Taichung, Taiwan.
  • Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
  • Isomura M; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.
Hum Mol Genet ; 23(20): 5492-504, 2014 Oct 15.
Article em En | MEDLINE | ID: mdl-24861553
Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Sanguíneas / Glicoproteínas / 5'-Nucleotidase / Cadeias Leves de Miosina / Miosinas Cardíacas / Povo Asiático / Aldeído Desidrogenase / Canal de Potássio KCNQ1 / Proteínas Secretadas Inibidoras de Proteinases / Obesidade Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Sanguíneas / Glicoproteínas / 5'-Nucleotidase / Cadeias Leves de Miosina / Miosinas Cardíacas / Povo Asiático / Aldeído Desidrogenase / Canal de Potássio KCNQ1 / Proteínas Secretadas Inibidoras de Proteinases / Obesidade Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2014 Tipo de documento: Article