Efficacy of bleeding risk scores in elderly patients with acute coronary syndromes.
Rev Esp Cardiol (Engl Ed)
; 67(6): 463-70, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24863595
ABSTRACT
INTRODUCTION AND OBJECTIVES:
The incidence of acute coronary syndromes is high in the elderly population. Bleeding is associated with a poorer prognosis in this clinical setting. The available bleeding risk scores have not been validated specifically in the elderly. Our aim was to assess predictive ability of the most important bleeding risk scores in patients with acute coronary syndrome aged ≥ 75 years.METHODS:
We prospectively included consecutive acute coronary syndromes patients. Baseline characteristics, laboratory findings, and hemodynamic data were collected. In-hospital bleeding was defined according to CRUSADE, Mehran, ACTION, and BARC definitions. CRUSADE, Mehran, and ACTION bleeding risk scores were calculated for each patient. The ability of these scores to predict major bleeding was assessed by binary logistic regression, receiver operating characteristic curves, and area under the curves.RESULTS:
We included 2036 patients, with mean age of 62.1 years; 369 patients (18.1%) were ≥ 75 years. Older patients had higher bleeding risk (CRUSADE, 42 vs 22; Mehran, 25 vs 15; ACTION, 36 vs 28; P<.001) and a slightly higher incidence of major bleeding events (CRUSADE bleeding, 5.1% vs 3.8%; P=.250). The predictive ability of these 3 scores was lower in the elderly (area under the curve, CRUSADE 0.63 in older patients, 0.81 in young patients; P=.027; Mehran 0.67 in older patients, 0.73 in younger patients; P=.340; ACTION 0.58 in older patients, 0.75 in younger patients; P=.041).CONCLUSIONS:
Current bleeding risk scores showed poorer predictive performance in elderly patients with acute coronary syndromes than in younger patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medição de Risco
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Síndrome Coronariana Aguda
/
Hemorragia
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article