Microdialysis pharmacokinetic study of scopolamine in plasma, olfactory bulb and vestibule after intranasal administration.

Wei, Yan; Ying, Mingzhen; Xu, Shuai; Wang, Feng; Zou, Aifeng; Cao, Shilei; Jiang, Xinguo; Wang, Yajie

Wei, Yan; Ying, Mingzhen; Xu, Shuai; Wang, Feng; Zou, Aifeng; Cao, Shilei; Jiang, Xinguo; Wang, Yajie.

Afiliação

Wei Y; a Department of Pharmaceutics, School of Pharmacy , Fudan University , Shanghai , China .
Ying M; b Department of Oncology, Changhai Hospital , Second Military Medical University , China .
Xu S; b Department of Oncology, Changhai Hospital , Second Military Medical University , China .
Wang F; c Shanghai Institute of Pharmaceutical Industry , Shanghai , China , and.
Zou A; d Department of Pharmaceutics , Yangtze river Pharmaceutical Group , Taizhou , China.
Cao S; a Department of Pharmaceutics, School of Pharmacy , Fudan University , Shanghai , China .
Jiang X; a Department of Pharmaceutics, School of Pharmacy , Fudan University , Shanghai , China .
Wang Y; b Department of Oncology, Changhai Hospital , Second Military Medical University , China .

Drug Deliv ; 23(1): 263-8, 2016.

Article em En | MEDLINE | ID: mdl-24865285

Assuntos

Antieméticos/administração & dosagem; Antieméticos/farmacocinética; Bulbo Olfatório/metabolismo; Escopolamina/administração & dosagem; Escopolamina/farmacocinética; Vestíbulo do Labirinto/metabolismo; Administração Intranasal; Animais; Disponibilidade Biológica; Sistemas de Liberação de Medicamentos; Microdiálise; Mucosa Olfatória/metabolismo; Ratos; Ratos Sprague-Dawley

Palavras-chave

Intranasal drug delivery; microdialysis; motion sickness; pharmacokinetics; scopolamine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bulbo Olfatório / Escopolamina / Vestíbulo do Labirinto / Antieméticos Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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