Effects of intrathecal caffeic acid phenethyl ester and methylprednisolone on oxidant/antioxidant status in traumatic spinal cord injuries.
J Neurol Surg A Cent Eur Neurosurg
; 76(1): 20-4, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-24871822
ABSTRACT
PURPOSE:
To examine the effect of intrathecally given caffeic acid phenethyl ester (CAPE) on peroxidation and total oxidant and antioxidant systems, and the effect of intrathecally given methylprednisolone (MP) in spinal cord injury (SCI) models. MATERIALS ANDMETHODS:
Four groups of 10 rats were formed (1) Laminectomy, intrathecal saline injection, no SCI (sham S); (2) Laminectomy, intrathecal saline injection, SCI (control SCI); (3) Laminectomy, intrathecally given single dose of 3 mg/kg MP, SCISCI (SCI + MP). 4) Laminectomy, intrathecally given single dose of 1 µg/kg CAPE, SCI (SCI + CAPE). Malondialdehyde (MDA), total oxidant activity (TOA), total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) values in the spinal cord tissue were evaluated.RESULTS:
When group S and group SCI were compared, MDA, TOA, and SOD parameters increased post-SCI (p < 0.01). When compared with group SCI, it was observed that CAPE and MP decreased the MDA, TOA, and SOD levels (p < 0.01). This decrease was more pronounced in the SCI + CAPE group. When group S and group SCI were compared, a statistically substantial decrease was observed in the post-SCI TAC levels. When compared with group SCI, it was shown that CAPE and MP treatment substantially increased TAC levels (p < 0.001).CONCLUSION:
Intrathecal injection of both CAPE and MP inhibits lipid peroxidation and increase of oxidants in SCIs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Álcool Feniletílico
/
Traumatismos da Medula Espinal
/
Ácidos Cafeicos
/
Metilprednisolona
/
Peroxidação de Lipídeos
/
Antioxidantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article