Effects of acute and sub-chronic L-dopa therapy on striatal L-dopa methylation and dopamine oxidation in an MPTP mouse model of Parkinsons disease.

Smith, Marquitta L; King, Jennifer; Dent, Lemuel; Mackey, Veronica; Muthian, Gladson; Griffin, Brenya; Charlton, Clivel G

Smith, Marquitta L; King, Jennifer; Dent, Lemuel; Mackey, Veronica; Muthian, Gladson; Griffin, Brenya; Charlton, Clivel G.

Afiliação

Smith ML; Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.
King J; University of Pennsylvania, 3451 Walnut Street, Philadelphia, PA 19104, USA.
Dent L; Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.
Mackey V; Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.
Muthian G; Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.
Griffin B; Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.
Charlton CG; Department of Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA. Electronic address: ccharlton@mmc.edu.

Life Sci ; 110(1): 1-7, 2014 Aug 06.

Article em En | MEDLINE | ID: mdl-24880075

Assuntos

Antiparkinsonianos/farmacologia; Catecol O-Metiltransferase/metabolismo; Dopamina/metabolismo; Levodopa/farmacologia; Transtornos Parkinsonianos/tratamento farmacológico; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina/administração & dosagem; Animais; Antiparkinsonianos/administração & dosagem; Corpo Estriado/metabolismo; Modelos Animais de Doenças; Esquema de Medicação; Levodopa/administração & dosagem; Masculino; Metilação; Camundongos; Camundongos Endogâmicos C57BL; Oxirredução; Transtornos Parkinsonianos/fisiopatologia; Fatores de Tempo

Palavras-chave

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); 3,4-Dihydroxyphenyalanine (l-dopa); 3,4-Dihydroxyphenyl acetic acid (DOPAC); 3-Methoxytyramine (3-MT); 3-O-methyldopa (3-OMD); Catechol-O-methyltransferase (COMT); Dopamine (DA); Homovanillic acid (HVA); Monoamine oxidase (MAO); Parkinson's disease (PD); l-dopa-induced dyskinesia (LID)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Levodopa / Catecol O-Metiltransferase / Transtornos Parkinsonianos / Antiparkinsonianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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