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Synthesis and preliminary evaluation of novel (99m)Tc-labeled folate derivative via click reaction for SPECT imaging.
Guo, Zhide; Zhang, Pu; Song, Manli; Wu, Xiaowei; Liu, Chang; Zhao, Zuoquan; Lu, Jie; Zhang, Xianzhong.
Afiliação
  • Guo Z; Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekou Outer Street, Beijing 100875, China. Electronic address: guozhide0518@gmail.com.
  • Zhang P; Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekou Outer Street, Beijing 100875, China; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Mol
  • Song M; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiang׳an South Road, Xiamen 361102, China.
  • Wu X; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiang׳an South Road, Xiamen 361102, China.
  • Liu C; Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekou Outer Street, Beijing 100875, China; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Mol
  • Zhao Z; Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekou Outer Street, Beijing 100875, China; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Mol
  • Lu J; Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekou Outer Street, Beijing 100875, China.
  • Zhang X; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiang׳an South Road, Xiamen 361102, China. Electronic address: zhangxzh@xmu.edu.cn.
Appl Radiat Isot ; 91: 24-30, 2014 Sep.
Article em En | MEDLINE | ID: mdl-24880914
ABSTRACT
The folate receptor is over expressed in a wide variety of human tumors. In this study, a novel (99m)Tc-labeled folate derivative ((99m)Tc-HYNIC-T-FA) was synthesized as a potential FR-targeting imaging probe and its efficiency was evaluated. This (99m)Tc-complex could be obtained through practical manner and showed improved in vivo characteristics compared with other radiofolates. Thus, this novel (99m)Tc-HYNIC-T-FA compound could serve as a potential imaging agent for folate receptor positive tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Organotecnécio / Neoplasias Nasofaríngeas / Compostos Radiofarmacêuticos / Ácido Fólico Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Organotecnécio / Neoplasias Nasofaríngeas / Compostos Radiofarmacêuticos / Ácido Fólico Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article