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Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema.
Hilfiker, Mark A; Hoang, Tram H; Cornil, Johan; Eidam, Hilary S; Matasic, Daniel S; Roethke, Theresa J; Klein, Michael; Thorneloe, Kevin S; Cheung, Mui.
Afiliação
  • Hilfiker MA; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
  • Hoang TH; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
  • Cornil J; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
  • Eidam HS; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
  • Matasic DS; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
  • Roethke TJ; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
  • Klein M; Platform Technology and Science, Molecular Discovery Research, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Thorneloe KS; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
  • Cheung M; Departments of Chemistry, Biology, and Drug Metabolism and Pharmacokinetics, Metabolic Pathways and Cardiovascular Therapeutic Area Unit, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
ACS Med Chem Lett ; 4(2): 293-6, 2013 Feb 14.
Article em En | MEDLINE | ID: mdl-24900661
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2013 Tipo de documento: Article