Molecular imaging reveals elevated VEGFR-2 expression in retinal capillaries in diabetes: a novel biomarker for early diagnosis.

Sun, Dawei; Nakao, Shintaro; Xie, Fang; Zandi, Souska; Bagheri, Abouzar; Kanavi, Mozhgan Rezaei; Samiei, Shahram; Soheili, Zahra-Soheila; Frimmel, Sonja; Zhang, Zhongyu; Ablonczy, Zsolt; Ahmadieh, Hamid; Hafezi-Moghadam, Ali

Sun, Dawei; Nakao, Shintaro; Xie, Fang; Zandi, Souska; Bagheri, Abouzar; Kanavi, Mozhgan Rezaei; Samiei, Shahram; Soheili, Zahra-Soheila; Frimmel, Sonja; Zhang, Zhongyu; Ablonczy, Zsolt; Ahmadieh, Hamid; Hafezi-Moghadam, Ali.

Afiliação

Sun D; Center for Excellence in Functional and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Radiology and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass
Nakao S; Center for Excellence in Functional and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Radiology and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass
Xie F; Center for Excellence in Functional and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Radiology and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass
Zandi S; Center for Excellence in Functional and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Radiology and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass
Bagheri A; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
Kanavi MR; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
Samiei S; Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran;
Soheili ZS; National Institute of Genetic Engineering and Biotechnology, Tehran, Iran; and.
Frimmel S; Center for Excellence in Functional and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Radiology and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass
Zhang Z; Center for Excellence in Functional and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Radiology and.
Ablonczy Z; Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina, USA.
Ahmadieh H; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
Hafezi-Moghadam A; Center for Excellence in Functional and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Radiology and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass

FASEB J ; 28(9): 3942-51, 2014 Sep.

Article em En | MEDLINE | ID: mdl-24903276

Assuntos

Biomarcadores/análise; Capilares/patologia; Retinopatia Diabética/diagnóstico; Imagem Molecular/métodos; Retina/patologia; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Idoso; Animais; Apoptose; Western Blotting; Capilares/metabolismo; Estudos de Casos e Controles; Proliferação de Células; Células Cultivadas; Diabetes Mellitus Experimental/complicações; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Tipo 1/complicações; Diabetes Mellitus Tipo 1/genética; Diabetes Mellitus Tipo 1/metabolismo; Diabetes Mellitus Tipo 2/complicações; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Retinopatia Diabética/genética; Retinopatia Diabética/metabolismo; Diagnóstico Precoce; Feminino; Humanos; Técnicas Imunoenzimáticas; Masculino; RNA Mensageiro/genética; Coelhos; Ratos Long-Evans; Reação em Cadeia da Polimerase em Tempo Real; Retina/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/genética

Palavras-chave

endothelial injury; preventive care; probe development; retinopathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Capilares / Biomarcadores / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Retinopatia Diabética / Imagem Molecular Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies / Screening_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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