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The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia.
Cao, Y; Hunter, Z R; Liu, X; Xu, L; Yang, G; Chen, J; Patterson, C J; Tsakmaklis, N; Kanan, S; Rodig, S; Castillo, J J; Treon, S P.
Afiliação
  • Cao Y; 1] Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA [2] Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Hunter ZR; 1] Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA [2] Department of Pathology, Boston University Medical School, Boston, MA, USA.
  • Liu X; 1] Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA [2] Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Xu L; Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
  • Yang G; 1] Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA [2] Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Chen J; Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
  • Patterson CJ; Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
  • Tsakmaklis N; Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
  • Kanan S; Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
  • Rodig S; 1] Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
  • Castillo JJ; 1] Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA [2] Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Treon SP; 1] Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA [2] Department of Medicine, Harvard Medical School, Boston, MA, USA.
Leukemia ; 29(1): 169-76, 2015 Jan.
Article em En | MEDLINE | ID: mdl-24912431
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Macroglobulinemia de Waldenstrom / Resistencia a Medicamentos Antineoplásicos / Receptores CXCR4 / MAP Quinases Reguladas por Sinal Extracelular / Proteínas Proto-Oncogênicas c-akt / Mutação / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Macroglobulinemia de Waldenstrom / Resistencia a Medicamentos Antineoplásicos / Receptores CXCR4 / MAP Quinases Reguladas por Sinal Extracelular / Proteínas Proto-Oncogênicas c-akt / Mutação / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article