Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.

Mesplède, Thibault; Osman, Nathan; Wares, Melissa; Quashie, Peter K; Hassounah, Said; Anstett, Kaitlin; Han, Yingshan; Singhroy, Diane N; Wainberg, Mark A

Mesplède, Thibault; Osman, Nathan; Wares, Melissa; Quashie, Peter K; Hassounah, Said; Anstett, Kaitlin; Han, Yingshan; Singhroy, Diane N; Wainberg, Mark A.

Afiliação

Mesplède T; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada.
Osman N; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Wares M; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Quashie PK; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Hassounah S; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Anstett K; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Han Y; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada.
Singhroy DN; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Wainberg MA; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montréal, Québec, Canada Division of Experimental Medicine, Faculty of Medicine, McGill Unive

J Antimicrob Chemother ; 69(10): 2733-40, 2014 Oct.

Article em En | MEDLINE | ID: mdl-24917583

Assuntos

Farmacorresistência Viral/genética; Inibidores de Integrase de HIV/farmacologia; Integrase de HIV/genética; HIV-1/efeitos dos fármacos; HIV-1/genética; Compostos Heterocíclicos com 3 Anéis/farmacologia; Mutação; Replicação Viral/efeitos dos fármacos; Substituição de Aminoácidos; Linhagem Celular; Ativação Enzimática/efeitos dos fármacos; Integrase de HIV/química; Integrase de HIV/metabolismo; Inibidores de Integrase de HIV/química; Compostos Heterocíclicos com 3 Anéis/química; Humanos; Testes de Sensibilidade Microbiana; Modelos Moleculares; Conformação Molecular; Oxazinas; Piperazinas; Ligação Proteica; Piridonas; Integração Viral/genética

Palavras-chave

HIV-1; antiviral; integrase inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Replicação Viral / HIV-1 / Inibidores de Integrase de HIV / Integrase de HIV / Farmacorresistência Viral / Compostos Heterocíclicos com 3 Anéis / Mutação Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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