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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
Cozen, W; Timofeeva, M N; Li, D; Diepstra, A; Hazelett, D; Delahaye-Sourdeix, M; Edlund, C K; Franke, L; Rostgaard, K; Van Den Berg, D J; Cortessis, V K; Smedby, K E; Glaser, S L; Westra, H-J; Robison, L L; Mack, T M; Ghesquieres, H; Hwang, A E; Nieters, A; de Sanjose, S; Lightfoot, T; Becker, N; Maynadie, M; Foretova, L; Roman, E; Benavente, Y; Rand, K A; Nathwani, B N; Glimelius, B; Staines, A; Boffetta, P; Link, B K; Kiemeney, L; Ansell, S M; Bhatia, S; Strong, L C; Galan, P; Vatten, L; Habermann, T M; Duell, E J; Lake, A; Veenstra, R N; Visser, L; Liu, Y; Urayama, K Y; Montgomery, D; Gaborieau, V; Weiss, L M; Byrnes, G; Lathrop, M.
Afiliação
  • Cozen W; 1] USC Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9175, USA [2].
  • Timofeeva MN; 1] International Agency for Research on Cancer (IARC), 69372 Lyon, France [2] Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, UK [3].
  • Li D; 1] [2].
  • Diepstra A; 1] University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands [2].
  • Hazelett D; 1] USC Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9175, USA [2].
  • Delahaye-Sourdeix M; 1] International Agency for Research on Cancer (IARC), 69372 Lyon, France [2].
  • Edlund CK; USC Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9175, USA.
  • Franke L; University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
  • Rostgaard K; Statens Serum Institut, DK-2300 Copenhagen, Denmark.
  • Van Den Berg DJ; USC Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9175, USA.
  • Cortessis VK; USC Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9175, USA.
  • Smedby KE; Karolinska Institutet and Karolinska University Hospital, S-221 00 Stockholm, Sweden.
  • Glaser SL; Cancer Prevention Institute of California, Fremont, California 94538, USA.
  • Westra HJ; University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
  • Robison LL; St Jude Children's Hospital, Cordova, Tennessee 38105, USA.
  • Mack TM; USC Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9175, USA.
  • Ghesquieres H; Centre Léon Bérard, UMR CNRS 5239-Université Lyon 1, 69008 Lyon, France.
  • Hwang AE; USC Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9175, USA.
  • Nieters A; University Medical Centre Freiburg, D-79085 Freiburg, Germany.
  • de Sanjose S; IDIBELL Institut Català d'Oncologia, 8907 Barcelona, Spain.
  • Lightfoot T; University of York, YO10 5DD York, UK.
  • Becker N; German Cancer Research Centre, D-69120 Heidelberg, Germany.
  • Maynadie M; CHU de Dijon, EA 4184, University of Burgundy, 21070 Dijon, France.
  • Foretova L; Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
  • Roman E; University of York, YO10 5DD York, UK.
  • Benavente Y; IDIBELL Institut Català d'Oncologia, 8907 Barcelona, Spain.
  • Rand KA; USC Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9175, USA.
  • Nathwani BN; City of Hope National Medical Center, Duarte, California 91010, USA.
  • Glimelius B; Uppsala University, 75285 Uppsala, Sweden.
  • Staines A; School of Nursing and Human Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Boffetta P; Icahn School of Medicine at Mount Sinai, New York City, New York 10029-6574, USA.
  • Link BK; University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
  • Kiemeney L; Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, The Netherlands.
  • Ansell SM; Mayo Clinic, Rochester, Minnesota 55905, USA.
  • Bhatia S; City of Hope National Medical Center, Duarte, California 91010, USA.
  • Strong LC; MD Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA.
  • Galan P; INSERM U557 (UMR Inserm; INRA; CNAM, Université Paris 13), 93017 Paris, France.
  • Vatten L; Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
  • Habermann TM; Mayo Clinic, Rochester, Minnesota 55905, USA.
  • Duell EJ; IDIBELL Institut Català d'Oncologia, 8907 Barcelona, Spain.
  • Lake A; MRC University of Glasgow Centre for Virus Research, Garscube Estate, University of Glasgow, G12 8QQ Glasgow, Scotland, UK.
  • Veenstra RN; University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
  • Visser L; University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
  • Liu Y; University of Groningen, University Medical Centre Groningen, 9700 RB Groningen, The Netherlands.
  • Urayama KY; Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo 104-0044, Japan.
  • Montgomery D; MRC University of Glasgow Centre for Virus Research, Garscube Estate, University of Glasgow, G12 8QQ Glasgow, Scotland, UK.
  • Gaborieau V; International Agency for Research on Cancer (IARC), 69372 Lyon, France.
  • Weiss LM; Clarient Pathology Services, Aliso Viejo, California 92656, USA.
  • Byrnes G; International Agency for Research on Cancer (IARC), 69372 Lyon, France.
  • Lathrop M; Genome Quebec, Montreal, Canada H3A 0G1.
Nat Commun ; 5: 3856, 2014 Jun 12.
Article em En | MEDLINE | ID: mdl-24920014
Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI) = 0.76-0.86, P(combined) = 3.5 × 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 19 / Doença de Hodgkin / Predisposição Genética para Doença / Fatores de Transcrição Hélice-Alça-Hélice Básicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 19 / Doença de Hodgkin / Predisposição Genética para Doença / Fatores de Transcrição Hélice-Alça-Hélice Básicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article