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Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity.
Zhou, Yuan; Wang, Yun; Rao, Li-Lin; Liang, Zhu-Yuan; Chen, Xiao-Ping; Zheng, Dang; Tan, Cheng; Tian, Zhi-Qiang; Wang, Chun-Hui; Bai, Yan-Qiang; Chen, Shan-Guang; Li, Shu.
Afiliação
  • Zhou Y; Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
  • Wang Y; Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences Beijing, China ; University of Chinese Academy of Sciences Beijing, China.
  • Rao LL; Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
  • Liang ZY; Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
  • Chen XP; National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center Beijing, China.
  • Zheng D; Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences Beijing, China ; University of Chinese Academy of Sciences Beijing, China.
  • Tan C; National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center Beijing, China.
  • Tian ZQ; National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center Beijing, China.
  • Wang CH; National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center Beijing, China.
  • Bai YQ; National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center Beijing, China.
  • Chen SG; National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center Beijing, China.
  • Li S; Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
Front Behav Neurosci ; 8: 200, 2014.
Article em En | MEDLINE | ID: mdl-24926242
ABSTRACT
Long-term spaceflight induces both physiological and psychological changes in astronauts. To understand the neural mechanisms underlying these physiological and psychological changes, it is critical to investigate the effects of microgravity on the functional architecture of the brain. In this study, we used resting-state functional MRI (rs-fMRI) to study whether the functional architecture of the brain is altered after 45 days of -6° head-down tilt (HDT) bed rest, which is a reliable model for the simulation of microgravity. Sixteen healthy male volunteers underwent rs-fMRI scans before and after 45 days of -6° HDT bed rest. Specifically, we used a commonly employed graph-based measure of network organization, i.e., degree centrality (DC), to perform a full-brain exploration of the regions that were influenced by simulated microgravity. We subsequently examined the functional connectivities of these regions using a seed-based resting-state functional connectivity (RSFC) analysis. We found decreased DC in two regions, the left anterior insula (aINS) and the anterior part of the middle cingulate cortex (MCC; also called the dorsal anterior cingulate cortex in many studies), in the male volunteers after 45 days of -6° HDT bed rest. Furthermore, seed-based RSFC analyses revealed that a functional network anchored in the aINS and MCC was particularly influenced by simulated microgravity. These results provide evidence that simulated microgravity alters the resting-state functional architecture of the brains of males and suggest that the processing of salience information, which is primarily subserved by the aINS-MCC functional network, is particularly influenced by spaceflight. The current findings provide a new perspective for understanding the relationships between microgravity, cognitive function, autonomic neural function, and central neural activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article