Evaluation of the neuroprotective activity of stansin 6, a resin glycoside from Ipomoea stans.
Bioorg Med Chem Lett
; 24(15): 3541-5, 2014 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-24928403
ABSTRACT
Stansin 6 a tetrasaccharide resin glycoside isolated from the root of Ipomoea stans was evaluated as anticonvulsant and neuroprotective in kainic acid-induced seizures of rats. Intraperitoneal injection of kainic acid (10 mg/kg) induced typical behavioral seizures such as wet dog shakes and limbic seizures, and histopathological changes in the hippocampus (degeneration and loss of pyramidal cells in CA1 to CA4 areas). Stansin 6 (10-80 mg/kg) had no effect on the behavior of rats and did not induce hippocampal damage. Pretreatment with stansin 6 inhibited convulsions in rats from kainic acid-induced seizures, reduced the degeneration pattern in the CA3 region, decreased astrocytic reactivity, and reduced the expression of IL-1ß and TNF-α induced by kainic acid. These results suggest that stansin 6 possesses neuroprotective and anticonvulsant activities.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
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Glicolipídeos
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Fármacos Neuroprotetores
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Ipomoea
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Hipocampo
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Anticonvulsivantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article