[New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy]. / Nouveaux rôles physiopathologiques pour le récepteur PLA2R1 dans le cancer et la glomérulonéphrite extramembraneuse.
Med Sci (Paris)
; 30(5): 519-25, 2014 May.
Article
em Fr
| MEDLINE
| ID: mdl-24939538
ABSTRACT
PLA2R1 is a large transmembrane receptor of 180-kDa that belongs to the superfamily of C-type lectins. It was discovered because of its high affinity for secreted phospholipases A2 (sPLA2), enzymes that play a key role in lipid mediator synthesis. Early PLA2R1 physiological roles include the clearance of sPLA2 from the extracellular medium and/or promotion of their actions. Over the last four years, two independent studies suggested that PLA2R1 plays a role in cancer as a tumor gene suppressor and is the major target antigen of auto-immune antibodies involved in idiopathic membranous nephropathy, a severe human kidney disease. These novel findings shed light on PLA2R1 and pave the way for its use as a reliable biomarker and an attractive therapeutic target in these diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glomerulonefrite Membranosa
/
Receptores da Fosfolipase A2
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Neoplasias
Limite:
Animals
/
Humans
Idioma:
Fr
Ano de publicação:
2014
Tipo de documento:
Article