Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer.
Future Oncol
; 10(7): 1187-202, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24947260
ABSTRACT
AIM:
To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. PATIENTS &METHODS:
Fifty-two GC and 23 control samples were included.RESULTS:
GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033).CONCLUSION:
GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Metaloproteinase 7 da Matriz
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MicroRNAs
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Fator 15 de Diferenciação de Crescimento
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article