Cilostazol and outcome in outpatients with peripheral artery disease.
Thromb Res
; 134(2): 331-5, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24951338
ABSTRACT
BACKGROUND:
Cilostazol increases the walking distance in patients with intermittent claudication, but there is scarce evidence of any effect on the risk for subsequent ischemic events, bleeding or death. PATIENTS ANDMETHODS:
We used data from the FRENA Registry to compare the clinical outcome in stable outpatients with intermittent claudication, according to the use of cilostazol.RESULTS:
As of January 2013, 1,317 patients with intermittent claudication were recruited in FRENA, of whom 191 (14.5%) received cilostazol. Over a mean follow-up of 18months, 39 patients developed myocardial infarction, 23 ischemic stroke, 20 underwent limb amputation, 15 had major bleeding and 70 died. There were no significant differences in the rate of subsequent ischemic events, major bleeding or death between patients receiving or not receiving cilostazol. On multivariate analysis, the use of cilostazol had no influence on the risk for subsequent myocardial infarction (hazard ratio [HR] 0.97; 95% CI 0.33-20.8), ischemic stroke (HR 1.46; 95% CI 0.48-4.43), limb amputation (HR 0.34; 95% CI 0.04-20.6), major bleeding (HR 1.52; 95% CI 0.33-7.09) or death (HR 0.90; 95% CI 0.40-20.0).CONCLUSIONS:
In stable outpatients with intermittent claudication, the use of cilostazol was not associated with increased rates of subsequent ischemic events, major bleeding or death.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tetrazóis
/
Doença Arterial Periférica
/
Inibidores da Fosfodiesterase 3
/
Fibrinolíticos
/
Claudicação Intermitente
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article