Your browser doesn't support javascript.
loading
The genomic landscape of nasopharyngeal carcinoma.
Lin, De-Chen; Meng, Xuan; Hazawa, Masaharu; Nagata, Yasunobu; Varela, Ana Maria; Xu, Liang; Sato, Yusuke; Liu, Li-Zhen; Ding, Ling-Wen; Sharma, Arjun; Goh, Boon Cher; Lee, Soo Chin; Petersson, Bengt Fredrik; Yu, Feng Gang; Macary, Paul; Oo, Min Zin; Ha, Chan Soh; Yang, Henry; Ogawa, Seishi; Loh, Kwok Seng; Koeffler, H Phillip.
Afiliação
  • Lin DC; 1] Cancer Science Institute of Singapore, National University of Singapore, Singapore. [2] Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California, USA. [3].
  • Meng X; 1] Cancer Science Institute of Singapore, National University of Singapore, Singapore. [2] Department of Medicine, School of Medicine, National University of Singapore, Singapore. [3].
  • Hazawa M; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Nagata Y; 1] Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. [2] Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Varela AM; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Xu L; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Sato Y; 1] Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. [2] Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Liu LZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Ding LW; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Sharma A; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Goh BC; 1] Cancer Science Institute of Singapore, National University of Singapore, Singapore. [2] Department of Haematology-Oncology, National University Cancer Institute, Singapore.
  • Lee SC; 1] Cancer Science Institute of Singapore, National University of Singapore, Singapore. [2] Department of Haematology-Oncology, National University Cancer Institute, Singapore.
  • Petersson BF; Department of Pathology, National University Health System, Singapore.
  • Yu FG; Department of Otolaryngology, National University Hospital Singapore, Singapore.
  • Macary P; Department of Immunology, National University of Singapore, Singapore.
  • Oo MZ; Department of Immunology, National University of Singapore, Singapore.
  • Ha CS; Department of Microbiology, National University of Singapore, Singapore.
  • Yang H; 1] Cancer Science Institute of Singapore, National University of Singapore, Singapore. [2].
  • Ogawa S; 1] Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. [2] Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. [3].
  • Loh KS; 1] Department of Otolaryngology, National University Hospital Singapore, Singapore. [2].
  • Koeffler HP; 1] Cancer Science Institute of Singapore, National University of Singapore, Singapore. [2] Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California, USA. [3] National University Cancer Institute, National Universi
Nat Genet ; 46(8): 866-71, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24952746
ABSTRACT
Nasopharyngeal carcinoma (NPC) has extremely skewed ethnic and geographic distributions, is poorly understood at the genetic level and is in need of effective therapeutic approaches. Here we determined the mutational landscape of 128 cases with NPC using whole-exome and targeted deep sequencing, as well as SNP array analysis. These approaches revealed a distinct mutational signature and nine significantly mutated genes, many of which have not been implicated previously in NPC. Notably, integrated analysis showed enrichment of genetic lesions affecting several important cellular processes and pathways, including chromatin modification, ERBB-PI3K signaling and autophagy machinery. Further functional studies suggested the biological relevance of these lesions to the NPC malignant phenotype. In addition, we uncovered a number of new druggable candidates because of their genomic alterations. Together our study provides a molecular basis for a comprehensive understanding of, and exploring new therapies for, NPC.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article