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Development of novel azabenzofuran TRPA1 antagonists as in vivo tools.
Copeland, Katrina W; Boezio, Alessandro A; Cheung, Eugene; Lee, Josie; Olivieri, Philip; Schenkel, Laurie B; Wan, Qian; Wang, Weiya; Wells, Mary C; Youngblood, Beth; Gavva, Narender R; Lehto, Sonya G; Geuns-Meyer, Stephanie.
Afiliação
  • Copeland KW; Department of Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA. Electronic address: kwoodin@amgen.com.
  • Boezio AA; Department of Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA. Electronic address: aboezio@amgen.com.
  • Cheung E; Department of Pharmaceutics, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA.
  • Lee J; Department of Neuroscience, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA.
  • Olivieri P; Department of Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA.
  • Schenkel LB; Department of Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA.
  • Wan Q; Department of Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA.
  • Wang W; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Wells MC; Department of Pharmacokinetics & Drug Metabolism, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA.
  • Youngblood B; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Gavva NR; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Lehto SG; Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Geuns-Meyer S; Department of Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA.
Bioorg Med Chem Lett ; 24(15): 3464-8, 2014 Aug 01.
Article em En | MEDLINE | ID: mdl-24953819
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bloqueadores dos Canais de Cálcio / Desenho de Fármacos / Canais de Potencial de Receptor Transitório / Canais de Cátion TRPC / Compostos Heterocíclicos com 3 Anéis / Proteínas do Tecido Nervoso Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bloqueadores dos Canais de Cálcio / Desenho de Fármacos / Canais de Potencial de Receptor Transitório / Canais de Cátion TRPC / Compostos Heterocíclicos com 3 Anéis / Proteínas do Tecido Nervoso Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article