One-step synthesis of diazaspiro[4.5]decane scaffolds with exocyclic double bonds.

Li, Lidong; Hu, Qiong; Zhou, Pingping; Xie, Haifeng; Zhang, Xiaorong; Zhang, Hao; Hu, Yadong; Yin, Fei; Hu, Yimin

Li, Lidong; Hu, Qiong; Zhou, Pingping; Xie, Haifeng; Zhang, Xiaorong; Zhang, Hao; Hu, Yadong; Yin, Fei; Hu, Yimin.

Afiliação

Li L; Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecular-Based Materials, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China. yiminhu@mail.ahnu.edu.cn.

Org Biomol Chem ; 12(29): 5356-9, 2014 Aug 07.

Article em En | MEDLINE | ID: mdl-24956492

ABSTRACT

ABSTRACT

Unactivated yne-en-ynes reacted with a range of substituted aryl halides in the presence of Pd(OAc)2-PPh3 to afford diazaspiro[4.5]decane with exocyclic double bonds. Three carbon-carbon bonds are formed in this domino reaction, which involves highly regioselective C-C coupling and spiro scaffold steps.

Assuntos

Alcanos/síntese química; Química Orgânica/métodos; Paládio/química; Compostos de Espiro/síntese química; Alcanos/química; Catálise; Cromatografia; Conformação Molecular; Compostos de Espiro/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Compostos de Espiro / Química Orgânica / Alcanos Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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