Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance.

Meakin, Paul J; Chowdhry, Sudhir; Sharma, Ritu S; Ashford, Fiona B; Walsh, Shaun V; McCrimmon, Rory J; Dinkova-Kostova, Albena T; Dillon, John F; Hayes, John D; Ashford, Michael L J

Meakin, Paul J; Chowdhry, Sudhir; Sharma, Ritu S; Ashford, Fiona B; Walsh, Shaun V; McCrimmon, Rory J; Dinkova-Kostova, Albena T; Dillon, John F; Hayes, John D; Ashford, Michael L J.

Afiliação

Meakin PJ; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Chowdhry S; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Sharma RS; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Ashford FB; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Walsh SV; Department of Pathology, Ninewells Hospital and Medical School, Tayside NHS Trust, Dundee, Scotland, United Kingdom.
McCrimmon RJ; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Dinkova-Kostova AT; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Dillon JF; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Hayes JD; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom m.l.j.ashford@dundee.ac.uk j.d.hayes@dundee.ac.uk.
Ashford ML; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom m.l.j.ashford@dundee.ac.uk j.d.hayes@dundee.ac.uk.

Mol Cell Biol ; 34(17): 3305-20, 2014 Sep.

Article em En | MEDLINE | ID: mdl-24958099

Assuntos

Cirrose Hepática Experimental/etiologia; Fator 2 Relacionado a NF-E2/deficiência; Hepatopatia Gordurosa não Alcoólica/etiologia; Proteínas Quinases Ativadas por AMP/metabolismo; Acetil-CoA Carboxilase/metabolismo; Animais; Dieta Hiperlipídica/efeitos adversos; Suscetibilidade a Doenças; Estresse do Retículo Endoplasmático; Resistência à Insulina; Metabolismo dos Lipídeos/genética; Lipogênese/genética; Fígado/metabolismo; Fígado/patologia; Cirrose Hepática Experimental/genética; Cirrose Hepática Experimental/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Hepatopatia Gordurosa não Alcoólica/genética; Hepatopatia Gordurosa não Alcoólica/metabolismo; Estresse Oxidativo; Fosforilação; Transdução de Sinais; Resposta a Proteínas não Dobradas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Hepatopatia Gordurosa não Alcoólica / Cirrose Hepática Experimental Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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