Transition-metal-free tunable chemoselective N functionalization of indoles with ynamides.
Angew Chem Int Ed Engl
; 53(32): 8333-7, 2014 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-24962338
ABSTRACT
Two unprecedented Nâ
functionalizations of indoles with ynamides are described. By varying the electron-withdrawing group on the ynamide nitrogen atom, either Z-indolo-etheneamides or indolo-amidines can be selectively obtained under the same metal-free reaction conditions. The scope and synthetic potential of these reactions, as well as some mechanistic insights provided by DFT calculations, are reported.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article