The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation.

Rahbek-Clemmensen, Troels; Bay, Tina; Eriksen, Jacob; Gether, Ulrik; Jørgensen, Trine Nygaard

Rahbek-Clemmensen, Troels; Bay, Tina; Eriksen, Jacob; Gether, Ulrik; Jørgensen, Trine Nygaard.

Afiliação

Rahbek-Clemmensen T; Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, and University of Copenhagen, DK-2200 Copenhagen, Denmark; Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, DK-2200 Copenhagen, Denm
Bay T; Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, and University of Copenhagen, DK-2200 Copenhagen, Denmark.
Eriksen J; Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, and University of Copenhagen, DK-2200 Copenhagen, Denmark; Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, DK-2200 Copenhagen, Denm
Gether U; Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, and University of Copenhagen, DK-2200 Copenhagen, Denmark; Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, DK-2200 Copenhagen, Denm
Jørgensen TN; Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, and University of Copenhagen, DK-2200 Copenhagen, Denmark.

J Biol Chem ; 289(33): 23004-23019, 2014 Aug 15.

Article em En | MEDLINE | ID: mdl-24973209

Assuntos

Endossomos/metabolismo; Lisossomos/metabolismo; Proteólise; Proteínas da Membrana Plasmática de Transporte de Serotonina/metabolismo; Carcinógenos/farmacologia; Endossomos/genética; Células HEK293; Humanos; Lisossomos/genética; Transporte Proteico/efeitos dos fármacos; Transporte Proteico/fisiologia; Proteínas da Membrana Plasmática de Transporte de Serotonina/genética; Acetato de Tetradecanoilforbol/farmacologia; Proteínas rab de Ligação ao GTP/genética; Proteínas rab de Ligação ao GTP/metabolismo; proteínas de unión al GTP Rab7

Palavras-chave

Cellular Regulation; Endocytosis; Intracellular Trafficking; Monoamine Transporter; Protein Kinase C (PKC); Protein Sorting; Serotonin Transporter

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endossomos / Proteínas da Membrana Plasmática de Transporte de Serotonina / Proteólise / Lisossomos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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