ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells.

Guedan, Sonia; Chen, Xi; Madar, Aviv; Carpenito, Carmine; McGettigan, Shannon E; Frigault, Matthew J; Lee, Jihyun; Posey, Avery D; Scholler, John; Scholler, Nathalie; Bonneau, Richard; June, Carl H

Guedan, Sonia; Chen, Xi; Madar, Aviv; Carpenito, Carmine; McGettigan, Shannon E; Frigault, Matthew J; Lee, Jihyun; Posey, Avery D; Scholler, John; Scholler, Nathalie; Bonneau, Richard; June, Carl H.

Afiliação

Guedan S; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Translational Research Laboratory, Institut d'Investigació Biomèdica de Bellvitge-Institut Català d'Oncologia, Barcelona, Spain;
Chen X; Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY;
Madar A; Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY;
Carpenito C; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;
McGettigan SE; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;
Frigault MJ; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;
Lee J; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;
Posey AD; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;
Scholler J; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;
Scholler N; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Stanford Research Institute International, Biosciences Division, Menlo Park, CA; and.
Bonneau R; Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY; Computer Science Department, Courant Institute of Mathematical Sciences, New York University, New York, NY.
June CH; Abramson Cancer Center and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

Blood ; 124(7): 1070-80, 2014 Aug 14.

Article em En | MEDLINE | ID: mdl-24986688

Assuntos

Proteína Coestimuladora de Linfócitos T Induzíveis/imunologia; Receptores de Antígenos de Linfócitos T/imunologia; Células Th1/imunologia; Células Th17/imunologia; Animais; Antígenos CD28/genética; Antígenos CD28/imunologia; Antígenos CD28/metabolismo; Complexo CD3/genética; Complexo CD3/imunologia; Complexo CD3/metabolismo; Linhagem Celular Tumoral; Células Cultivadas; Citometria de Fluxo; Humanos; Imunoterapia Adotiva/métodos; Proteína Coestimuladora de Linfócitos T Induzíveis/metabolismo; Subunidade gama Comum de Receptores de Interleucina/genética; Interleucina-17/imunologia; Interleucina-17/metabolismo; Interleucinas/imunologia; Interleucinas/metabolismo; Células K562; Camundongos Endogâmicos NOD; Camundongos Knockout; Camundongos SCID; Receptores de Antígenos de Linfócitos T/genética; Receptores de Antígenos de Linfócitos T/metabolismo; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/imunologia; Proteínas Recombinantes de Fusão/metabolismo; Transdução de Sinais/genética; Transdução de Sinais/imunologia; Células Th1/metabolismo; Células Th17/metabolismo; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/genética; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia; Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto; Interleucina 22

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Células Th1 / Células Th17 / Proteína Coestimuladora de Linfócitos T Induzíveis Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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