Stiff person-syndrome IgG affects presynaptic GABAergic release mechanisms.
J Neural Transm (Vienna)
; 122(3): 357-62, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-24990310
ABSTRACT
The majority of patients with stiff person-syndrome (SPS) are characterized by autoantibodies to glutamate decarboxylase 65 (GAD65). In previous passive-transfer studies, SPS immunoglobulin G (IgG) induced SPS core symptoms. We here provide evidence that SPS-IgG causes a higher frequency of spontaneous vesicle fusions. Sustained GABAergic transmission and presynaptic GABAergic vesicle pool size remained unchanged. Since these findings cannot be attributed to anti-GAD65 autoantibodies alone, we propose that additional autoantibodies with so far undefined antigen specificity might affect presynaptic release mechanisms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
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Rigidez Muscular Espasmódica
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Terminações Pré-Sinápticas
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Potenciais Pós-Sinápticos Inibidores
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Neurônios GABAérgicos
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Glutamato Descarboxilase
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article