Intrafetal glucose infusion alters glucocorticoid signaling and reduces surfactant protein mRNA expression in the lung of the late-gestation sheep fetus.

McGillick, Erin V; Morrison, Janna L; McMillen, I Caroline; Orgeig, Sandra

McGillick, Erin V; Morrison, Janna L; McMillen, I Caroline; Orgeig, Sandra.

Afiliação

McGillick EV; Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia; and Molecular and Evolutionary Physiology of the Lung Laboratory, School of Pharmacy and Medical Sciences,
Morrison JL; Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia; and.
McMillen IC; Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia; and.
Orgeig S; Molecular and Evolutionary Physiology of the Lung Laboratory, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia sandra.orgeig@unisa.edu.au.

Am J Physiol Regul Integr Comp Physiol ; 307(5): R538-45, 2014 Sep 01.

Article em En | MEDLINE | ID: mdl-24990855

Assuntos

Feto/metabolismo; Glucocorticoides/metabolismo; Glucose/farmacologia; Pulmão/metabolismo; Surfactantes Pulmonares/metabolismo; RNA Mensageiro/metabolismo; Ovinos/fisiologia; Transdução de Sinais/efeitos dos fármacos; 11-beta-Hidroxiesteroide Desidrogenase Tipo 1/metabolismo; Animais; Gasometria; Peso Corporal/efeitos dos fármacos; Peso Corporal/fisiologia; Feminino; Glucose/metabolismo; Insulina/metabolismo; Pulmão/embriologia; Modelos Animais; Gravidez; Prenhez; Receptor IGF Tipo 1/metabolismo; Receptores de Glucocorticoides/metabolismo; Ovinos/embriologia; Transdução de Sinais/fisiologia

Palavras-chave

diabetes; glucose; obesity; surfactant

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Surfactantes Pulmonares / RNA Mensageiro / Ovinos / Transdução de Sinais / Feto / Glucocorticoides / Glucose / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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