Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis.

Sozen, Erdi; Karademir, Betul; Yazgan, Burak; Bozaykut, Perinur; Ozer, Nesrin Kartal

Sozen, Erdi; Karademir, Betul; Yazgan, Burak; Bozaykut, Perinur; Ozer, Nesrin Kartal.

Afiliação

Sozen E; Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, 34668 Haydarpasa, Istanbul, Turkey.
Karademir B; Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, 34668 Haydarpasa, Istanbul, Turkey.
Yazgan B; Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, 34668 Haydarpasa, Istanbul, Turkey.
Bozaykut P; Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, 34668 Haydarpasa, Istanbul, Turkey.
Ozer NK; Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, 34668 Haydarpasa, Istanbul, Turkey.

Redox Biol ; 2: 732-8, 2014.

Article em En | MEDLINE | ID: mdl-25009774

Assuntos

Proteína Quinase 8 Ativada por Mitógeno/metabolismo; Complexo de Endopeptidases do Proteassoma/metabolismo; Animais; Aorta/metabolismo; Aorta/patologia; Aterosclerose/etiologia; Aterosclerose/metabolismo; Colesterol/sangue; Colesterol na Dieta; Expressão Gênica/efeitos dos fármacos; Hipercolesterolemia/complicações; Hipercolesterolemia/metabolismo; Masculino; Malondialdeído/sangue; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; Proteína Quinase 8 Ativada por Mitógeno/genética; Fosforilação/efeitos dos fármacos; RNA Mensageiro/metabolismo; Coelhos; Transdução de Sinais/efeitos dos fármacos; Vitamina E/sangue; Vitamina E/farmacologia

Palavras-chave

AP-1; AP-1, activator protein-1; Atherosclerosis; CD36, cluster of differentiation 36; ERAD, endoplasmic-reticulum-associated protein degradation; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HPLC, high-performance liquid chromatography; Hypercholesterolemia; JNK, c-Jun amino terminal kinase; JNK1; LDL, low density lipoprotein; MAPK, mitogen-activated protein kinase; MDA, malondialdehyde; MMP, matrix metallo proteinase; Proteasome; TBA, thiobarbituric acid; TNF a, tumor necrosis factor a; UPS, ubiquitin-proteasome system; Vitamin E; oxLDL, oxidized low density lipoprotein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexo de Endopeptidases do Proteassoma / Proteína Quinase 8 Ativada por Mitógeno Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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