Low midlife blood pressure, survival, comorbidity, and health-related quality of life in old age: the Helsinki Businessmen Study.
J Hypertens
; 32(9): 1797-804, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25014505
ABSTRACT
OBJECTIVE:
The aim of the present study was to examine the long-term impact of midlife blood pressure (BP) on mortality, comorbidity, and health-related quality of life (HRQoL) in old age.METHODS:
These are longitudinal analyses of the Helsinki Businessmen Study, a cohort of business executives, born in 1919-1934, whose BP was measured between 1964 and 1973 (nâ=â3267). Comorbidity and HRQoL with RAND-36 [Short Form (SF)-36] were assessed from questionnaires in 2000; mortality up to 31 July 2012 was ascertained from national registers. Baseline BP was categorized as normal, less than 120â mmHg systolic and less than 80 âmmHg diastolic (nâ=â121); prehypertension, 120-139 âmmHg systolic or 80-89â mmHg diastolic (nâ=â2131); stage 1 hypertension, 140-159âmmHg systolic or 90-99â mmHg diastolic (nâ=â757); and stage 2 hypertension, more than 160 âmmHg systolic or more than 100â mmHg diastolic (nâ=â258). Main outcome measures were long-term mortality, comorbidity, and HRQoL in old age.RESULTS:
During the 48-year follow-up, 2013 men (61.6%) died. There was a graded relationship between BP and total mortality (Pâ<â0.001). The men with normal BP had the lowest mortality; the age-adjusted difference in mean survival was 7.5 years between the normal and stage 2 baseline BP groups, and 11.2 months between normal and prehypertension groups. Lower BP in midlife was associated with better scores in the physical functioning (P-linear trend <0.001) and general health (Pâ=â0.01) scales of RAND-36 in old age. RAND-36 scales associated with mental health were not affected by midlife BP.CONCLUSION:
Lower BP in midlife is associated with longer life and better physical HRQoL in old age.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Pressão Sanguínea
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Nível de Saúde
/
Hipertensão
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Hipotensão
/
Longevidade
Limite:
Adult
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Aged
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article