Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity.
Fitoterapia
; 98: 84-90, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25016952
ABSTRACT
Scrodentosides A-E (1-5), five new acylated iridoid glycosides, together with 19 known ones, were isolated from the whole plant of Scrophularia dentata Royle ex Benth. The structures of these isolated glycosides were elucidated by spectroscopic methods. Bioassay showed that compounds 7 and 11 had significant inhibitory effect against NF-κB activation with IC50 value of 43.7 µM and 1.02 µM respectively.
Palavras-chave
8-O-acetylharpagide (PubChem CID: 160879); Ajugol(PubChem CID: 6452750); Ajugoside (PubChem CID: 179611); Anti-inflammation; Cis-harpagoside (PubChem CID: 13889700); Geniposidic acid(PubChem CID: 443354); Iridoid glycosides; NF-κB; Scrophularia dentata; Scropolioside D (PubChem CID: 6918700); Trans-harpagoside (PubChem CID: 5281542); harpagide (PubChem CID: 93045)
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
/
Scrophularia
/
Glicosídeos Iridoides
/
Anti-Inflamatórios
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article