Immunizations with unmodified tumor cells and simultaneous COX-2 inhibition eradicate malignant rat brain tumors and induce a long-lasting CD8(+) T cell memory.

Eberstål, Sofia; Fritzell, Sara; Sandén, Emma; Visse, Edward; Darabi, Anna; Siesjö, Peter

Eberstål, Sofia; Fritzell, Sara; Sandén, Emma; Visse, Edward; Darabi, Anna; Siesjö, Peter.

Afiliação

Eberstål S; Glioma Immunotherapy Group, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden; Lund Stem Cell Center, BMC B10, Lund University, SE-221 84 Lund, Sweden. Electronic address: sofia.eberstal@med.lu.se.
Fritzell S; Glioma Immunotherapy Group, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden.
Sandén E; Glioma Immunotherapy Group, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden.
Visse E; Glioma Immunotherapy Group, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden.
Darabi A; Glioma Immunotherapy Group, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden.
Siesjö P; Glioma Immunotherapy Group, Division of Neurosurgery, Department of Clinical Sciences, Lund University, Barngatan 2B, SE-221 85 Lund, Sweden.

J Neuroimmunol ; 274(1-2): 161-7, 2014 Sep 15.

Article em En | MEDLINE | ID: mdl-25022336

Assuntos

Neoplasias Encefálicas/tratamento farmacológico; Linfócitos T CD8-Positivos/efeitos dos fármacos; Inibidores de Ciclo-Oxigenase 2/farmacologia; Glioma/tratamento farmacológico; Memória Imunológica/efeitos dos fármacos; Animais; Neoplasias Encefálicas/imunologia; Neoplasias Encefálicas/patologia; Linfócitos T CD8-Positivos/imunologia; Linhagem Celular Tumoral; Modelos Animais de Doenças; Glioma/imunologia; Glioma/patologia; Imunização/métodos; Memória Imunológica/imunologia; Interferon gama/sangue; Interferon gama/imunologia; Masculino; Ratos; Ratos Endogâmicos F344

Palavras-chave

CD8(+) T cells; COX-2 inhibition; Immunological memory; Immunotherapy; Malignant brain tumors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Linfócitos T CD8-Positivos / Inibidores de Ciclo-Oxigenase 2 / Glioma / Memória Imunológica Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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