Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer.

Leong, Hui Sun; Chong, Fui Teen; Sew, Pui Hoon; Lau, Dawn P; Wong, Bernice H; Teh, Bin-Tean; Tan, Daniel S W; Iyer, N Gopalakrishna

Leong, Hui Sun; Chong, Fui Teen; Sew, Pui Hoon; Lau, Dawn P; Wong, Bernice H; Teh, Bin-Tean; Tan, Daniel S W; Iyer, N Gopalakrishna.

Afiliação

Leong HS; Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore.
Chong FT; Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore.
Sew PH; Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore.
Lau DP; Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore.
Wong BH; Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore.
Teh BT; Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore.
Tan DS; Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore gopaliyer@yahoo.com Daniel.tan.s.w@nccs.com.sg.
Iyer NG; Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore gopaliyer@yahoo.com Daniel.tan.s.w@nccs.com.sg.

Stem Cells Transl Med ; 3(9): 1055-65, 2014 Sep.

Article em En | MEDLINE | ID: mdl-25024430

Assuntos

Carcinoma de Células Escamosas/metabolismo; Fator de Crescimento Epidérmico/metabolismo; Neoplasias de Cabeça e Pescoço/metabolismo; Fator de Crescimento Insulin-Like I/metabolismo; Células-Tronco Neoplásicas/metabolismo; Transdução de Sinais/fisiologia; Adulto; Western Blotting; Carcinoma de Células Escamosas/patologia; Linhagem Celular Tumoral; Receptores ErbB/metabolismo; Feminino; Citometria de Fluxo; Neoplasias de Cabeça e Pescoço/patologia; Humanos; Fator 4 Semelhante a Kruppel; Masculino; Pessoa de Meia-Idade; Células-Tronco Neoplásicas/patologia; Receptor IGF Tipo 1/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Carcinoma de Células Escamosas de Cabeça e Pescoço

Palavras-chave

Aldehyde dehydrogenase; Cancer stem cell; Epidermal growth factor receptor; Head and neck squamous cell cancer; Insulin-like growth factor-1 receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Fator de Crescimento Insulin-Like I / Carcinoma de Células Escamosas / Transdução de Sinais / Fator de Crescimento Epidérmico / Neoplasias de Cabeça e Pescoço Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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