Multifunctional inorganic nanocontainers for DNA and drug delivery into living cells.
Chemistry
; 20(35): 10900-4, 2014 Aug 25.
Article
em En
| MEDLINE
| ID: mdl-25042168
ABSTRACT
The design and synthesis of multifunctional nanomaterials could lead to applications relevant for biomedicine. Manufacturing porous particles to make them able to carry bioactive molecules into living cells represents a substantial goal towards the development of powerful tools for nanomedicine. This work describes a first example of using zeolite-L crystals as multifunctional nanocontainers to simultaneously deliver DNA oligonucleotides and organic molecules into living cells. Multifunctional zeolite-L was prepared by filling the pore system with guest molecules, whilst DNA was adsorbed electrostatically on their surface. The release kinetics of DNA and of the guest molecules into living cells was studied to prove the multiple-drug-delivery ability of the system. The localization of all the components in different cellular compartments was followed. The presented system may be a prototype for the development of novel nanoparticles for drug delivery and gene therapy.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
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Sistemas de Liberação de Medicamentos
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Nanopartículas
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article