Synthesis and duplex-stabilizing properties of fluorinated N-methanocarbathymidine analogues locked in the C3'-endo conformation.
Angew Chem Int Ed Engl
; 53(37): 9893-7, 2014 Sep 08.
Article
em En
| MEDLINE
| ID: mdl-25044699
ABSTRACT
The efficient synthesis, antiviral activity, and duplex-stabilizing properties of both isomers of the 2'-fluoro analogue of Northern methanocarbathymidine (N-MCT), 2 and 3, are reported. We show that 2'-F incorporation on the N-MCT scaffold has a strong stabilizing effect on duplex thermal stability.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Timidina
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article