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Usefulness of serum bilirubin levels as a biomarker for long-term clinical outcomes after percutaneous coronary intervention.
Kim, Hyun-Wook; Choi, Dong-Hyun; Lim, Leejin; Lee, Young-Min; Kang, Joon Tae; Chae, Seung Seok; Ki, Young-Jae; Song, Heesang; Koh, Young-Youp.
Afiliação
  • Kim HW; Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea.
  • Choi DH; Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea. dhchoi@chosun.ac.kr.
  • Lim L; Department of Biomaterials, Chosun University Graduate School, Gwangju, 501-759, Republic of Korea.
  • Lee YM; Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea.
  • Kang JT; Department of Internal Medicine, Mokpo Jung-ang General Hospital, Mokpo, Republic of Korea.
  • Chae SS; Department of Internal Medicine, Mokpo Jung-ang General Hospital, Mokpo, Republic of Korea.
  • Ki YJ; Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea.
  • Song H; Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju, 501-759, Republic of Korea.
  • Koh YY; Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of Korea.
Heart Vessels ; 30(6): 728-33, 2015 Nov.
Article em En | MEDLINE | ID: mdl-25048679
The aim of this study was to evaluate the prognostic value of serum total bilirubin on the development of adverse outcomes after percutaneous coronary intervention (PCI) besides high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP). Serum total bilirubin, hs-cTnT, and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary endpoint was cardiac death. There were 21 events of cardiac death during a mean of 25.8 months of follow-up. When the serum total bilirubin cut-off level (median value) was set to 0.58 mg/dL using the receiver operating characteristic curve, the sensitivity was 95.2 % and the specificity was 51.0 % for differentiating between the group with cardiac death and the group without cardiac death. Kaplan-Meier analysis revealed that the lower serum total bilirubin group (<0.58 mg/dL) had a significantly higher cardiac death rate than the higher serum total bilirubin group (≥0.58 mg/dL) (10.4 vs. 0.6 %, log-rank: P = 0.0001). In conclusion, low serum total bilirubin is a predictive marker for cardiac death after PCI.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Bilirrubina / Troponina T / Peptídeo Natriurético Encefálico / Morte / Intervenção Coronária Percutânea Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Bilirrubina / Troponina T / Peptídeo Natriurético Encefálico / Morte / Intervenção Coronária Percutânea Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article