Control of axon-axon attraction by Semaphorin reverse signaling.
Proc Natl Acad Sci U S A
; 111(31): 11383-8, 2014 Aug 05.
Article
em En
| MEDLINE
| ID: mdl-25049408
ABSTRACT
Semaphorin family proteins are well-known axon guidance ligands. Recent studies indicate that certain transmembrane Semaphorins can also function as guidance receptors to mediate axon-axon attraction or repulsion. The mechanisms by which Semaphorin reverse signaling modulates axon-surface affinity, however, remain unknown. In this study, we reveal a novel mechanism underlying upregulation of axon-axon attraction by Semaphorin-1a (Sema1a) reverse signaling in the developing Drosophila visual system. Sema1a promotes the phosphorylation and activation of Moesin (Moe), a member of the ezrin/radixin/moesin family of proteins, and downregulates the level of active Rho1 in photoreceptor axons. We propose that Sema1a reverse signaling activates Moe, which in turn upregulates Fas2-mediated axon-axon attraction by inhibiting Rho1.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Transdução de Sinais
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Semaforinas
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Drosophila melanogaster
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article