Effect of pharmacological intervention on MIP-1α, MIP-1ß and MCP-1 expression in patients with psoriasis vulgaris.

ABSTRACT

OBJECTIVE: To detect the expression level of macrophage inflammatory protein-1 (MIP-1)α, MIP-1ß and monocyte chemoattractant protein-1 (MCP-1) in with psoriasis vulgaris and explore the role in the pathogenesis of psoriasis vulgaris. METHODS: The level of MIP-1α, MIP-1ß and MCP-1 in peripheral blood from 50 patients with psoriasis vulgaris and 50 normal controls were measured by enzyme linked immunosorbent assay. The correlation with psoriasis area and severity index (PASI) was analyzed. The level of MIP-1α, MIP-1ß and MCP-1 was compared between psoriasis vulgaris patients at active stage and resting stage. And the change in MIP-1α, MIP-1ß and MCP-1 before and after therapy was also observed. RESULTS: The content of MIP-1α, MIP-1ß and MCP-1 in patients with psoriasis vulgaris was (1342.78 ± 210.30), (175.28 ± 28.18) and (266.86 ± 32.75) ng/L, respectively, significantly higher than those in control group (P<0.05). The expression level of MIP-1α, MIP-1ß and MCP-1 in peripheral blood of patients with psoriasis vulgaris was positively correlated with PASI (P<0.01). After acitretin therapy, expression level of MIP-1α, MIP-1ß and MCP-1 in peripheral blood of patients with psoriasis vulgaris was significantly decreased. CONCLUSIONS: Chemokine factor MIP-1α, MIP-1ß and MCP-1 may be involved in the pathogenesis of psoriasis vulgaris.