An acute clinical comparison of corneal staining and comfort associated with contact lens care solutions.
Cont Lens Anterior Eye
; 37(5): 351-7, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25070393
ABSTRACT
PURPOSE:
This study compared the biocompatibility and comfort of 4 lens care solutions currently marketed in France.METHODS:
This was a randomized, interventional, double-masked, single-center crossover study assessing balafilcon A silicone hydrogel contact lenses, bilaterally, straight from the blister pack solution (control) and pre-soaked in the following lens care solutions Regard(®) (containing sodium chlorite), ReNu(®) (containing a PHMB [polyhexamethylene biguanide] derivative), CyClean™ and MeniCare™ Soft (both containing PHMB). Subjects were randomized to the order of test solution use. For each of the 5 solutions tested, subjects attended a baseline/lens dispensing visit and an intervention visit 2h later. At both visits, evaluation included slit-lamp examination, corrected-distance visual acuity, corneal staining, and subject-assessed photophobia, ocular comfort, and ocular redness.RESULTS:
Thirty subjects were enrolled and 28 were evaluable. Corneal staining severity was significantly worse than baseline after 2h of wearing lenses soaked in CyClean, MeniCare, or ReNu (P≤0.001). The MeniCare group alone demonstrated a significant improvement in ocular comfort after 2h of lens wear (P=0.02). No group demonstrated significant changes in ocular redness or photophobia. Corrected-distance visual acuity was similar between baseline and intervention visits for each test solution. No adverse events were reported during the study.CONCLUSIONS:
Silicone hydrogel contact lenses presoaked in lens solutions containing PHMB or a PHMB derivative produced an increase in corneal staining after 2h of lens wear. The higher levels of corneal staining in the 2 solutions did not correlate with increased discomfort within this 2-h timeframe.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Erros de Refração
/
Soluções para Lentes de Contato
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Lentes de Contato Hidrofílicas
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Córnea
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article