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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Flach, Johanna; Bakker, Sietske T; Mohrin, Mary; Conroy, Pauline C; Pietras, Eric M; Reynaud, Damien; Alvarez, Silvia; Diolaiti, Morgan E; Ugarte, Fernando; Forsberg, E Camilla; Le Beau, Michelle M; Stohr, Bradley A; Méndez, Juan; Morrison, Ciaran G; Passegué, Emmanuelle.
Afiliação
  • Flach J; 1] The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Hem/Onc Division, University of California San Francisco, San Francisco, California 94143, USA [2] Institute of Experimental Cancer Research, Comprehensive Cancer Center, 89081 Ulm, Germany.
  • Bakker ST; The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Hem/Onc Division, University of California San Francisco, San Francisco, California 94143, USA.
  • Mohrin M; The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Hem/Onc Division, University of California San Francisco, San Francisco, California 94143, USA.
  • Conroy PC; Center for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.
  • Pietras EM; The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Hem/Onc Division, University of California San Francisco, San Francisco, California 94143, USA.
  • Reynaud D; The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Hem/Onc Division, University of California San Francisco, San Francisco, California 94143, USA.
  • Alvarez S; Spanish National Cancer Research Centre (CNIO), E-28049 Madrid, Spain.
  • Diolaiti ME; Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA.
  • Ugarte F; Institute for the Biology of Stem Cells, Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.
  • Forsberg EC; Institute for the Biology of Stem Cells, Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.
  • Le Beau MM; Section of Hematology/Oncology and the Comprehensive Cancer Center, University of Chicago, Chicago, Illinois 60637, USA.
  • Stohr BA; Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA.
  • Méndez J; Spanish National Cancer Research Centre (CNIO), E-28049 Madrid, Spain.
  • Morrison CG; Center for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.
  • Passegué E; The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Hem/Onc Division, University of California San Francisco, San Francisco, California 94143, USA.
Nature ; 512(7513): 198-202, 2014 Aug 14.
Article em En | MEDLINE | ID: mdl-25079315
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Células-Tronco Hematopoéticas / Senescência Celular / Replicação do DNA Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Células-Tronco Hematopoéticas / Senescência Celular / Replicação do DNA Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article