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Clinical course in a patient with neutrophil-specific granule deficiency and rapid detection of neutrophil granules as a screening test.
Shigemura, Tomonari; Yamazaki, Takashi; Shiohara, Masaaki; Kobayashi, Norimoto; Naganuma, Kuniaki; Koike, Kenich; Agematsu, Kazunaga.
Afiliação
  • Shigemura T; Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 390-8621, Japan.
J Clin Immunol ; 34(7): 780-3, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25081842
ABSTRACT

PURPOSE:

Neutrophil-specific granule deficiency (SGD) is a rare, congenital disorder characterized by atypical neutrophil structure and function that results in frequent and severe bacterial infections. However, the clinical course of patients with SGD have not been described in detail because of the scarcity of the disease. We present the clinical course of an adult patient with SGD and propose a method for making an early diagnosis of SGD. PATIENT AND

METHODS:

A32-year-old Japanese woman with SGD had a small impetigo lesion on her face and experienced the rapid spread of a facial abscess to a pulmonary abscess via the blood stream. We also analyzed the expression of neutrophil granule proteins in our patient compared with a healthy control by flow cytometry.

RESULTS:

We confirmed defects of several neutrophil granule proteins in our patient by flow cytometry.

CONCLUSION:

Severe bacterial infections sometimes occur and spread rapidly in SGD. Detection of neutrophil granules by flow cytometry is useful for a rapid diagnosis and a screening of SGD.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Secretórias / Síndromes de Imunodeficiência / Impetigo / Abscesso Pulmonar / Neutrófilos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Adult / Female / Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Secretórias / Síndromes de Imunodeficiência / Impetigo / Abscesso Pulmonar / Neutrófilos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Adult / Female / Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2014 Tipo de documento: Article