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TGFß induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes.
Liu, Liang; Zhou, Weiying; Cheng, Chun-Ting; Ren, Xiubao; Somlo, George; Fong, Miranda Y; Chin, Andrew R; Li, Hui; Yu, Yang; Xu, Yang; O'Connor, Sean Timothy Francis; O'Connor, Timothy R; Ann, David K; Stark, Jeremy M; Wang, Shizhen Emily.
Afiliação
  • Liu L; Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Zhou W; Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. Department of Pharmacology, College of Pharmacy, The Third Military Medical University, Chongqing, China.
  • Cheng CT; Department of Molecular Pharmacology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. City of Hope Irell and Manella Graduate School of Biological Sciences, Duarte, California.
  • Ren X; Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Somlo G; Department of Medical Oncology, City of Hope Beckman Research Institute and Medical Center, Duarte, California.
  • Fong MY; Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California.
  • Chin AR; Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. City of Hope Irell and Manella Graduate School of Biological Sciences, Duarte, California.
  • Li H; Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Yu Y; Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Xu Y; Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California.
  • O'Connor ST; Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California.
  • O'Connor TR; Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California.
  • Ann DK; Department of Molecular Pharmacology, City of Hope Beckman Research Institute and Medical Center, Duarte, California.
  • Stark JM; Department of Radiation Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California.
  • Wang SE; Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. ewang@coh.org.
Mol Cancer Res ; 12(11): 1597-609, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25103497
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Fator de Crescimento Transformador beta / Proteína BRCA1 / Reparo do DNA / Inibidores de Poli(ADP-Ribose) Polimerases Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Fator de Crescimento Transformador beta / Proteína BRCA1 / Reparo do DNA / Inibidores de Poli(ADP-Ribose) Polimerases Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article