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Non-small-cell lung cancer resectability: diagnostic value of PET/MR.
Fraioli, Francesco; Screaton, Nicholas J; Janes, Samuel M; Win, Thida; Menezes, Leon; Kayani, Irfan; Syed, Rizwan; Zaccagna, Fulvio; O'Meara, Celia; Barnes, Anna; Bomanji, Jamshed B; Punwani, Shonit; Groves, Ashley M.
Afiliação
  • Fraioli F; Department of Nuclear Medicine and Radiology, University College London Hospitals NHS Foundation Trust, 235 Euston Road, London, NW1 2BU, UK, fraioli.francesco@gmail.com.
Eur J Nucl Med Mol Imaging ; 42(1): 49-55, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25120040
PURPOSE: To assess the diagnostic performance of PET/MR in patients with non-small-cell lung cancer. METHODS: Fifty consecutive consenting patients who underwent routine (18)F-FDG PET/CT for potentially radically treatable lung cancer following a staging CT scan were recruited for PET/MR imaging on the same day. Two experienced readers, unaware of the results with the other modalities, interpreted the PET/MR images independently. Discordances were resolved in consensus. PET/MR TNM staging was compared to surgical staging from thoracotomy as the reference standard in 33 patients. In the remaining 17 nonsurgical patients, TNM was determined based on histology from biopsy, imaging results (CT and PET/CT) and follow-up. ROC curve analysis was used to assess accuracy, sensitivity and specificity of the PET/MR in assessing the surgical resectability of primary tumour. The kappa statistic was used to assess interobserver agreement in the PET/MR TNM staging. Two different readers, without knowledge of the PET/MR findings, subsequently separately reviewed the PET/CT images for TNM staging. The generalized kappa statistic was used to determine intermodality agreement between PET/CT and PET/MR for TNM staging. RESULTS: ROC curve analysis showed that PET/MR had a specificity of 92.3 % and a sensitivity of 97.3 % in the determination of resectability with an AUC of 0.95. Interobserver agreement in PET/MR reading ranged from substantial to perfect between the two readers (Cohen's kappa 0.646 - 1) for T stage, N stage and M stage. Intermodality agreement between PET/CT and PET/MR ranged from substantial to almost perfect for T stage, N stage and M stage (Cohen's kappa 0.627 - 0.823). CONCLUSION: In lung cancer patients PET/MR appears to be a robust technique for preoperative staging.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Tomografia por Emissão de Pósitrons / Imagem Multimodal / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Evaluation_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Tomografia por Emissão de Pósitrons / Imagem Multimodal / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Evaluation_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article