Mitochondrial macro-haplogroup JT may play a protective role in ovarian ageing.
Mitochondrion
; 18: 1-6, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25132080
ABSTRACT
This study of 200 Caucasian women shows that the distribution of the mtDNA macro-haplogroups in patients with diminished ovarian reserve (DOR) differed significantly from that of patients with normal ovarian reserve (NOR) (p=0.02). The JT macro-haplogroup was significantly under-represented in DOR patients compared with NOR patients (p=0.006) and compared with the estimated frequency of 18.8% in the general French population (p=0.0012). Our findings suggest that the risk of a prematurely depleted ovarian reserve would be three times lower for patients carrying the JT macro-haplogroup than for patients with any of the other mtDNA haplogroups (odds ratio 0.3; 95% CI 0.13-0.74). If these preliminary results are confirmed in larger independent studies, they should lead to the better management of infertility.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Haplótipos
/
Envelhecimento
/
Mitocôndrias
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article