Synthesis and structure-activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives.

Han, Fangbin; Lin, Songwen; Liu, Peng; Tao, Jing; Yi, Chongqin; Xu, Heng

Han, Fangbin; Lin, Songwen; Liu, Peng; Tao, Jing; Yi, Chongqin; Xu, Heng.

Afiliação

Han F; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No.29 Life Science Park Road, Changping District, Beijing 102206, PR China.
Lin S; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No.29 Life Science Park Road, Changping District, Beijing 102206, PR China.
Liu P; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No.29 Life Science Park Road, Changping District, Beijing 102206, PR China.
Tao J; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No.29 Life Science Park Road, Changping District, Beijing 102206, PR China.
Yi C; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No.29 Life Science Park Road, Changping District, Beijing 102206, PR China.
Xu H; PKUCare Pharmaceutical R&D Center, A106-109, Biotech Innovation Works, No.29 Life Science Park Road, Changping District, Beijing 102206, PR China. Electronic address: xuheng@pkucare-pharm.com.

Bioorg Med Chem Lett ; 24(18): 4538-4541, 2014 Sep 15.

Article em En | MEDLINE | ID: mdl-25139570

Assuntos

Inibidores de Fosfoinositídeo-3 Quinase; Inibidores de Proteínas Quinases/farmacologia; Pirimidinas/farmacologia; Serina-Treonina Quinases TOR/antagonistas & inibidores; Cristalografia por Raios X; Relação Dose-Resposta a Droga; Humanos; Modelos Moleculares; Estrutura Molecular; Fosfatidilinositol 3-Quinases/metabolismo; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Pirimidinas/síntese química; Pirimidinas/química; Relação Estrutura-Atividade; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

Anti-tumor activity; Dual inhibitor; Mammalian target of rapamycin; Phosphoinositide 3-kinase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Inibidores de Fosfoinositídeo-3 Quinase Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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