Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion.
EMBO Rep
; 15(10): 1062-8, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25141863
ABSTRACT
How the p53 transcription factor/tumor suppressor inhibits cell invasion is poorly understood. We demonstrate that this function of p53 requires its direct interaction with p21(WAF1), a transcriptional target of p53, and that both p21 and p53 bind to Slug, which promotes cell invasion. Functional studies reveal that p21 and p53 cooperate to facilitate Mdm2-dependent Slug degradation and that this p53 function is mimicked by p53(R273H), a mutant lacking trans-activating activity. These actions of p21 and p53 are induced by γ-irradiation of cells and also operate in vivo. This is the first study to elucidate a mechanism involving p53 and p21 cooperation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Proteína Supressora de Tumor p53
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Inibidor de Quinase Dependente de Ciclina p21
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Neoplasias Pulmonares
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Invasividade Neoplásica
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article