Nickel-catalyzed substitution reactions of propargyl halides with organotitanium reagents.
Org Biomol Chem
; 12(38): 7634-42, 2014 Oct 14.
Article
em En
| MEDLINE
| ID: mdl-25143149
ABSTRACT
A simple and mild catalytic coupling reaction of propargyl halides with organotitanium reagents is reported. The reaction of propargyl bromide with organo-titanium reagents mediated by NiCl2 (2 mol%) and PCy3 (4 mol%) in CH2Cl2 afforded coupling product allenes in good to excellent yields (up to 95%) at room temperature. However, NiCl2(PPh3)2 was the best catalyst for substituted propargyl halides to yield allenes or alkynes preferentially. On the basis of the experimental results, a possible catalytic cycle has been proposed.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Pargilina
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Titânio
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Níquel
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article