CDK2 transcriptional repression is an essential effector in p53-dependent cellular senescence-implications for therapeutic intervention.

Zalzali, Hasan; Nasr, Bilal; Harajly, Mohamad; Basma, Hussein; Ghamloush, Farah; Ghayad, Sandra; Ghanem, Noël; Evan, Gerard I; Saab, Raya

Zalzali, Hasan; Nasr, Bilal; Harajly, Mohamad; Basma, Hussein; Ghamloush, Farah; Ghayad, Sandra; Ghanem, Noël; Evan, Gerard I; Saab, Raya.

Afiliação

Zalzali H; Department of Pediatric and Adolescent Medicine, American University of Beirut, Beirut, Lebanon. hz13@aub.edu.lb rs88@aub.edu.lb.
Nasr B; Department of Pediatric and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
Harajly M; Department of Pediatric and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
Basma H; Department of Pediatric and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
Ghamloush F; Department of Pediatric and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
Ghayad S; Department of Pediatric and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
Ghanem N; Department of Biology, American University of Beirut, Beirut, Lebanon.
Evan GI; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Saab R; Department of Pediatric and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.

Mol Cancer Res ; 13(1): 29-40, 2015 Jan.

Article em En | MEDLINE | ID: mdl-25149358

Assuntos

Senescência Celular/genética; Quinase 2 Dependente de Ciclina/genética; Dano ao DNA/genética; Neoplasias/genética; Proteína Supressora de Tumor p53/genética; Animais; Pontos de Checagem do Ciclo Celular/genética; Proliferação de Células/genética; Quinase 2 Dependente de Ciclina/antagonistas & inibidores; Regulação Neoplásica da Expressão Gênica; Humanos; Camundongos; Camundongos Transgênicos; Neoplasias/patologia; Transdução de Sinais/genética; Proteína Supressora de Tumor p53/biossíntese

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Proteína Supressora de Tumor p53 / Senescência Celular / Quinase 2 Dependente de Ciclina / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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