Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.

Xie, Yi; Zhao, Qiu Yue; Li, Hong Yan; Zhou, Xin; Liu, Yang; Zhang, Hong

Xie, Yi; Zhao, Qiu Yue; Li, Hong Yan; Zhou, Xin; Liu, Yang; Zhang, Hong.

Afiliação

Xie Y; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Nanch
Zhao QY; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Nanch
Li HY; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Nanch
Zhou X; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Nanch
Liu Y; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Nanch
Zhang H; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Nanchang Road, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Nanch

Pharmacol Biochem Behav ; 126: 181-6, 2014 Nov.

Article em En | MEDLINE | ID: mdl-25159739

Assuntos

Antioxidantes/metabolismo; Transtornos Cognitivos/tratamento farmacológico; Curcumina/uso terapêutico; Íons Pesados/efeitos adversos; Fator 2 Relacionado a NF-E2/metabolismo; Transdução de Sinais/efeitos dos fármacos; Animais; Fatores de Transcrição de Zíper de Leucina Básica/metabolismo; Encéfalo/efeitos dos fármacos; Encéfalo/metabolismo; Transtornos Cognitivos/etiologia; Curcumina/farmacologia; Feminino; Heme Oxigenase-1/metabolismo; Masculino; Malondialdeído/metabolismo; Aprendizagem em Labirinto/efeitos da radiação; Proteínas de Membrana/metabolismo; Camundongos; NADH NADPH Oxirredutases/metabolismo; Peptídeo Sintases/metabolismo; Radiação; Protetores contra Radiação/farmacologia; Protetores contra Radiação/uso terapêutico; Superóxido Dismutase/metabolismo; Regulação para Cima/efeitos dos fármacos

Palavras-chave

(12)C(6+) irradiation; Cerebral injuries; Curcumin; Mice; Nrf2 pathway; Oxidative stress

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Transtornos Cognitivos / Íons Pesados / Curcumina / Fator 2 Relacionado a NF-E2 / Antioxidantes Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google