[Diagnosis of thrombosis by hemostatic markers].
Nihon Rinsho
; 72(7): 1232-6, 2014 Jul.
Article
em Ja
| MEDLINE
| ID: mdl-25163313
ABSTRACT
Hemostatic markers are measured when diagnosing cases presenting with either thrombosis or thrombophilia. Decreased antithrombin (AT), protein C and protein S levels, and positive anti-phospholipid antibody findings together suggest a risk for venous thromboembolism (VTE). Increased thrombin AT complex (TAT) and soluble fibrin (SF) levels indicate a hypercoagulable state, and the addition of elevated fibrinogen and fibrin degradation products (FDP) as well as D-dimer suggests the presence of VTE. D-dimer is frequently measured in VTE cases, but this marker is affected by fibrinolysis and requires standardization. The prothrombin time, FDP and fibrinogen are all used in the diagnosis of disseminated intravascular coagulation. Markedly reduced ADAMTS13 level is a useful sign for the diagnosis of thrombotic thrombocytopenic purpura.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombose
/
Biomarcadores
/
Fibrinólise
/
Hemostasia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Ja
Ano de publicação:
2014
Tipo de documento:
Article