C-2 selective arylation of indoles with heterogeneous nanopalladium and diaryliodonium salts.
Chemistry
; 20(42): 13531-5, 2014 Oct 13.
Article
em En
| MEDLINE
| ID: mdl-25169833
A simple and efficient method to prepare synthetically useful 2-arylindoles is presented, using a heterogeneous Pd catalyst and diaryliodonium salts in water under mild conditions. A remarkably low leaching of metal catalyst was observed under the applied conditions. The developed protocol is highly C-2 selective and tolerates structural variations both in the indole and in the diaryliodonium salt. Arylations of both N-H indoles and N-protected indoles with ortho-substituted, electron-rich, electron-deficient, or halogenated diaryliodonium salts were achieved to give the desired products in high to excellent isolated yields within 6 to 15 h at room temperature or 40 °C.
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MEDLINE
Assunto principal:
Paládio
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Sais
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Hidrocarbonetos Aromáticos
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Indóis
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Iodo
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article